{"product_id":"spcas9-nls-1","title":"SpCas9-NLS","description":"SpCas9-NLS is an RNA-guided endonuclease from Streptococcus pyogenes. Guided by crRNA and tracrRNA (or a sgRNA formed by their fusion), SpCas9-NLS recognizes the region immediately upstream of the PAM sequence (5'-NGG) in double-stranded DNA targets and produces a double-stranded break precisely three nucleotides upstream of the PAM. SpCas9-NLS is commonly employed for gene editing. To enhance cellular editing efficiency, SpCas9-NLS contains a nuclear localization sequence (NLS) derived from Simian virus 40 (SV40) T antigen on N-termini. Additionally, this product can be utilized for the cleavage of target DNA in vitro and gene cloning, etc.","brand":"Cleavion","offers":[{"title":"1000 pmol","offer_id":57094768230775,"sku":"CLV-0192","price":428.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0991\/7097\/6119\/files\/CLV-0192-0-cleavion.png?v=1778840207","url":"https:\/\/cleavion.com\/products\/spcas9-nls-1","provider":"Cleavion","version":"1.0","type":"link"}