• RNase A
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RNase A

RNase A

CLV-0181

$82.86 USD
$28.57 USD $82.86 USD
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Product Specifications

  • Description

    Ribonuclease A (RNase A) is an endoribonuclease that specifically degrades single-stranded RNA at C and U residues. It cleaves the phosphodiester bond between the 5'-ribose of a nucleotide and the phosphate group attached to the 3'-ribose of an adjacent pyrimidine nucleotide. The resulting 2', 3'-cyclic phosphate is hydrolyzed to the corresponding 3'-nucleoside phosphate. RNase A exhibits the highest activity in cleaving single-stranded RNA and demonstrates varying activities under different reaction conditions. At low salt concentrations (0~100 mM NaCl), RNase A cleaves single-stranded and double-stranded RNA as well the RNA strand in RNA-DNA hybrids. However, at NaCl concentrations of 0.3 M or higher, RNase A specifically cleaves single-stranded RNA.

  • Category

    Modification and Cloning

  • Sub Category

    RNA Tool Enzymes

  • Components

    • RNase A: 100 mg

  • Storage Conditions

    -20°C

  • Shipping Conditions

    2~8°C

RNase A

Ribonuclease A (RNase A) is an endoribonuclease that specifically degrades single-stranded RNA at C and U residues. It cleaves the phosphodiester bond between the 5'-ribose of a nucleotide and the phosphate group attached to the 3'-ribose of an adjacent pyrimidine nucleotide. The resulting 2', 3'-cyclic phosphate is hydrolyzed to the corresponding 3'-nucleoside phosphate. RNase A exhibits the highest activity in cleaving single-stranded RNA and demonstrates varying activities under different reaction conditions. At low salt concentrations (0~100 mM NaCl), RNase A cleaves single-stranded and double-stranded RNA as well the RNA strand in RNA-DNA hybrids. However, at NaCl concentrations of 0.3 M or higher, RNase A specifically cleaves single-stranded RNA.